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You might focus on vitamins, minerals, or botanical extracts when you think of supplements. Yet every formula includes extra materials. Many brands call them “other ingredients,” and some even label them “inactive.” These items do more than fill space. They shape the pill, improve flavor, and influence how well you absorb nutrients. They also affect shelf life. Some can trigger negative reactions, so they are not always harmless. Consumers should pay close attention to these so-called “other ingredients.”
Manufacturers use these dyes in tablets, capsules, and foods. They have been linked to severe allergies. Tartrazine has been previously shown to cause asthma [1], [2].
Many brands include lactose in tablets and capsules. It often causes severe gastrointestinal distress—such as cramps and diarrhea [3]. Infants are also at risk. They may develop hypersensitivity, leading to joint pain, eczema, or bloating due to improper metabolism [4].
Starch is a widely used “other ingredient” that serves as a diluent, binder, or disintegrant. Its nature makes it prone to microbial contamination. This can lead to the growth of fungi known to produce carcinogenic toxins [5], [6], [7].
Used in supplements and pharmaceuticals as a binder and anti-caking agent. However, magnesium stearate may reduce tablets solubility, particularly for highly soluble or ionized compounds potentially making a supplement you are taking far less effective [8], [9].
A whitening and UV-protecting agent in food, cosmetics and supplements, TiO₂ is classified as “possibly carcinogenic” when inhaled. Studies suggest ingesting nano-sized TiO₂ (E171) may cause inflammation and oxidative stress [10], [11].
A common filler, maltodextrin may contribute to inflammatory bowel disease and metabolic syndrome. Additionally, research indicates that maltodextrin may encourage the growth of harmful bacteria, including strains associated with Crohn’s disease. In mice, maltodextrin has been shown to promote bacterial biofilm formation and alter the gut microbiome, potentially leading to inflammation and digestive problems [12], [13], [14], [15].
Aspartame is a sugar substitute and is about 180–200 times sweeter than sugar. It is commonly found in diet sodas, candy and supplements. Studies link aspartame to metabolic issues, neurological concerns like headaches and depression, and a potential increase in neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Some studies suggest aspartame may be linked to issues like preterm birth and allergic diseases in offspring when consumed during pregnancy. Research on rats has also shown that aspartame intake during pregnancy and lactation could lead to obesity and metabolic problems in male offspring [16], [17], [18], [19], [13], [21], [22].
One of the most debated concerns is its potential carcinogenic effects. Research suggests that aspartame may breaks down into harmful formaldehyde, a substance linked to cancer development [23], [24].
Once considered harmless, sucralose may contribute to systemic inflammation, liver damage, and gut microbiome disruption, leading to metabolic issues [25], [26], [27] and [28].
A clinical trial found that even small amounts of carrageenan, given in capsules, may trigger earlier relapse in ulcerative colitis patients in remission. Patients receiving placebo capsules had no relapses, while those receiving carrageenan-containing capsules did relapse. Notably, the capsules contained far less carrageenan than a typical diet, yet still had harmful effects on gut health [29].
Common food emulsifiers like polysorbate 80 (P80) and carboxymethylcellulose (CMC) can directly harm your gut microbiome. One study found that these additives make gut bacteria more likely to cause inflammation leading to gut issues and increasing the risk of chronic diseases [30].
While some fillers—such as microcrystalline cellulose—are generally considered safe for most people [31], they can still cause bloating or allergic reactions in sensitive individuals. Others, like silica, present more serious concerns depending on the route of exposure. For instance, inhaling large quantities of silica has been linked to significant health risks, including damage to the respiratory, renal, and immune systems, and has even been associated with lung cancer [32]. These risks highlight the importance of choosing additive-free supplements whenever possible to minimize unnecessary exposure to potentially harmful substances.
Fillers and other ingredients in supplements are everywhere. While many are approved for use, ongoing research continues to reveal their potential health effects. Whether you choose to avoid certain additives or simply stay informed, understanding the science behind them can help you make better choices for your well-being.
The best supplement brands avoid unnecessary fillers, artificial dyes, and questionable additives. They prioritize purity, list every ingredient, and classify absorption agents correctly. By eliminating unnecessary additives, they give customers confidence in their health choices.
At Atempo Natural, we are committed to clean formulas with high-quality active ingredients and no fillers—despite the increased financial cost. Because your health deserves only the best.
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